GWAS-related eQTLs across different cancer types
We identified 337,131 eQTLs that overlap with GWAS linkage disequilibrium (LD) regions (r² ≥ 0.5).
|
Cancer type
|
eQTL type
|
tagSNP
|
Gene position (hg19)
|
p-value
|
|||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| THYM | cis | rs1451375 | 1 | rs2329342 | chr7:50624971 | FIGNL1 | chr7:50511834-50518088:- | 0.3 | 4.64 | 1.09E-5 | Malaria |
| THYM | cis | rs2564921 | 1 | rs2336723 | chr3:53106047 | RFT1 | chr3:53122503-53164470:- | -0.42 | -4.8 | 5.83E-6 | Height |
| THYM | cis | rs2028299 | 1 | rs2351706 | chr15:90384115 | AP3S2 | chr15:90373832-90456222:- | -0.43 | -4.89 | 4.09E-6 | Type 2 diabetes |
| THYM | cis | rs2028299 | 1 | rs2351707 | chr15:90384045 | AP3S2 | chr15:90373832-90456222:- | -0.43 | -4.89 | 4.09E-6 | Type 2 diabetes |
| THYM | cis | rs11723261 | 1 | rs2353605 | chr4:219538 | ZNF718 | chr4:53272-156488:+ | 0.5 | 5.43 | 4.41E-7 | Immune response to smallpox vaccine (IL-6) |
| THYM | cis | rs4660306 | 1 | rs2356559 | chr1:45981512 | CCDC163P | chr1:45960581-45965646:- | -0.84 | -13.85 | 1.56E-24 | Homocysteine levels |
| THYM | cis | rs4660306 | 1 | rs2356561 | chr1:45980862 | CCDC163P | chr1:45960581-45965646:- | -0.8 | -13.18 | 3.67E-23 | Homocysteine levels |
| THYM | cis | rs2239557 | 1 | rs2358628 | chr14:74631757 | LIN52 | chr14:74551656-74667117:+ | -0.41 | -7.88 | 5.51E-12 | Common traits (Other) |
| THYM | cis | rs2239557 | 1 | rs2358633 | chr14:74647418 | LIN52 | chr14:74551656-74667117:+ | -0.39 | -7.16 | 1.73E-10 | Common traits (Other) |
| THYM | cis | rs454422 | 1 | rs236104 | chr20:5958960 | MCM8 | chr20:5931298-5975829:+ | -0.21 | -4.4 | 2.79E-5 | HIV-1 viral setpoint |
| THYM | cis | rs454422 | 1 | rs236121 | chr20:5972594 | MCM8 | chr20:5931298-5975829:+ | -0.2 | -4.21 | 5.84E-5 | HIV-1 viral setpoint |
| THYM | cis | rs9876781 | 1 | rs2362450 | chr3:48461313 | TREX1 | chr3:48501186-48509043:+ | -0.28 | -4.25 | 5.05E-5 | Longevity |
| THYM | cis | rs9876781 | 1 | rs2362452 | chr3:48418214 | TREX1 | chr3:48501186-48509043:+ | 0.28 | 4.43 | 2.52E-5 | Longevity |
| THYM | cis | rs7589728 | 1 | rs2363731 | chr2:88521793 | THNSL2 | chr2:88469835-88486145:+ | -0.5 | -4.23 | 5.34E-5 | Plasma clusterin levels |
| THYM | cis | rs10935120 | 1 | rs2370578 | chr3:134199612 | ANAPC13 | chr3:134196547-134204865:- | 0.58 | 7.97 | 3.55E-12 | Height |